Calcium alginate gel beads were prepared from a range of well characterized alginates. The physical properties of beads depended strongly on the composition, sequential structure, and molecular size of the polymers. Beads with the highest mechanical strength, lowest shrinkage, best stability towards monovalent cations, and highest porosity were made from alginate with a content of L-guluronic acid higher than 70% and an average length of the G-blocks higher than 15. For these "high G" alginates the critical overlap intrinsic viscosities have been determined, and for molecular weight higher than 2.4 x 10(5), the gel strength was independent of the molecular weight.
Strand BL, Mørch YA, Syvertsen KR, Espevik T, Skjåk-Braek G. Strand BL, et al. J Biomed Mater Res A. 2003 Mar 1;64(3):540-50. doi: 10.1002/jbm.a.10337. J Biomed Mater Res A. 2003. PMID: 12579569
Draget KI, Stokke BT, Yuguchi Y, Urakawa H, Kajiwara K. Draget KI, et al. Biomacromolecules. 2003 Nov-Dec;4(6):1661-8. doi: 10.1021/bm034105g. Biomacromolecules. 2003. PMID: 14606893
Donati I, Draget KI, Borgogna M, Paoletti S, Skjåk-Braek G. Donati I, et al. Biomacromolecules. 2005 Jan-Feb;6(1):88-98. doi: 10.1021/bm040053z. Biomacromolecules. 2005. PMID: 15638508
Mørch YA, Holtan S, Donati I, Strand BL, Skjåk-Braek G. Mørch YA, et al. Biomacromolecules. 2008 Sep;9(9):2360-8. doi: 10.1021/bm8003572. Epub 2008 Aug 15. Biomacromolecules. 2008. PMID: 18702546
Remminghorst U, Rehm BH. Remminghorst U, et al. Biotechnol Lett. 2006 Nov;28(21):1701-12. doi: 10.1007/s10529-006-9156-x. Epub 2006 Aug 16. Biotechnol Lett. 2006. PMID: 16912921 Review.
Wuttke B, Ekat K, Chabanovska O, Jackszis M, Springer A, Vasudevan P, Kreikemeyer B, Lang H. Wuttke B, et al. J Funct Biomater. 2024 May 15;15(5):129. doi: 10.3390/jfb15050129. J Funct Biomater. 2024. PMID: 38786639 Free PMC article.
Quiroz VM, Wang Y, Rakoski AI, Kasinathan D, Neshat SY, Hollister-Lock J, Doloff JC. Quiroz VM, et al. Adv Biol (Weinh). 2024 Aug;8(8):e2300502. doi: 10.1002/adbi.202300502. Epub 2024 Jan 20. Adv Biol (Weinh). 2024. PMID: 38243878
Lupu A, Gradinaru LM, Gradinaru VR, Bercea M. Lupu A, et al. Gels. 2023 May 2;9(5):376. doi: 10.3390/gels9050376. Gels. 2023. PMID: 37232968 Free PMC article. Review.
Malektaj H, Drozdov AD, deClaville Christiansen J. Malektaj H, et al. Int J Mol Sci. 2023 Mar 7;24(6):5064. doi: 10.3390/ijms24065064. Int J Mol Sci. 2023. PMID: 36982139 Free PMC article.
Maher S, Smith LA, El-Khoury CA, Kalil H, Sossey-Alaoui K, Bayachou M. Maher S, et al. Molecules. 2023 Feb 7;28(4):1612. doi: 10.3390/molecules28041612. Molecules. 2023. PMID: 36838600 Free PMC article.